Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Recruiting now · Not applicable

Conditions studied: Parkinson Disease

In brief

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

Key facts

Study ID

NCT05307055

Run by

University of Southern California

People needed

40

Starts

2022-01-11

Expected to finish

2029-08-31

Last updated by the study team

2025-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation
• Age >18 years old
• Stable medication regimen for at least 3 months.
• Patient informed and able to give written consent
• Able to comply with all testing, follow-ups and study appointments and protocols

You may not qualify if…

• History of epilepsy or seizure
• History of dementia
• History of major substance abuse

Where it is running

• University of Southern California Keck School of Medicine — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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