NA-AION Risk Factors: New Perspectives

Completed

Conditions studied: Non-arteritic Ischemic Optic Neuropathy, Optic Disk Drusen

In brief

The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with anatomical and vascular characteristics of the optic nerve.

Key facts

Study ID

NCT05305079

Run by

Rigshospitalet, Denmark

People needed

179

Starts

2021-08-01

Expected to finish

2024-08-31

Last updated by the study team

2024-11-22

Who can join

Age: 11 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of first episode of NA-AION in study eye with symptom onset within 1 month prior
• Subject age: Age >10
• NA-AION diagnosis requires:
• disc edema seen by site PI or by referring doctor
• visual field defect in the study eye consistent with NA-AION and mean deviation worse than 3.0 dB using the study visual field examination protocol
• relative afferent pupillary defect (unless the fellow eye had previous NA-AION or other optic nerve or retinal disease that is not exclusionary)

You may not qualify if…

• Previous episode of NA-AION in the study eye only
• Intraocular pressure of >21 mm Hg in the study eye
• Clinical or pathological evidence of giant cell arteritis
• Diseases that may affect the optic nerve: glaucoma, multiple sclerosis, Alzheimer disease, and Parkinson disease. Evidence of optic disc drusen and optic nerve hypoplasia are not exclusion criteria given they are important parts of the study. We will not exclude significant retinal diseases, since they may be related to underlying etiologies giving rise to ODD, such as macular degeneration, retinal dystrophies, but eyes with significant retinal diseases will be analyzed separately.

Where it is running

• Stanford Medicine — Palo Alto, California, United States
• UCSF Medical Center — San Francisco, California, United States
• University og Colorado — Boulder, Colorado, United States
• Massachusetts Eye and Ear — Boston, Massachusetts, United States
• John A. Moran Eye Center — Salt Lake City, Utah, United States
• Sydney Eye Hospital — Sydney, Australia
• University of Calgary — Calgary, Canada
• Research St. Joseph's — Hamilton, Canada
• Lawson Health Research Institute — London, Canada
• Aalborg University Hospital — Aalborg, Denmark
• Aarhus University Hospital — Aarhus, Denmark
• Odense University Hospital — Odense, Denmark
• Zealand University Hospital — Roskilde, Denmark
• Bordeaux University Hospital — Bordeaux, France
• Farabi Eye Hospital — Tehran, Iran
• Sheba Medical Center — Tel Aviv, Israel
• Capital and Coast DHB — Wellington, New Zealand
• University of Cambridge — Cambridge, United Kingdom
• King's College Hospital — London, United Kingdom
• Moorfield's Eye Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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