Fully Automated High-Throughput Quantitative MRI of the Liver

Recruiting now

Conditions studied: Healthy, Iron Overload, Liver Fat

In brief

The purpose of this research is to see if a new automated magnetic resonance imaging (MRI) method will be able to improve the images taken of the liver. Participants will have either known or suspected liver disease, known or suspected iron overload syndrome, or be a healthy adult. Participants will be in the research study for one day.

Key facts

Study ID

NCT05294471

Run by

University of Wisconsin, Madison

People needed

200

Starts

2023-10-16

Expected to finish

2026-09-01

Last updated by the study team

2026-03-12

Who can join

Age: 7 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 years or older

You may not qualify if…

• Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
• Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
• Eligibility Criteria for Substudy 3
• Inclusion Criteria:
• Age 7 years or older
• One of:
• Known or suspected liver iron overload
• Known or suspected elevated liver fat
• Exclusion Criteria:
• Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
• Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
• The subject has their own prescription for the medication.
• The informed consent process is conducted prior to the self-administration of this medication
• They come to the research visit with a driver
• Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
• Eligibility Criteria for Substudy 6
• Inclusion Criteria:
• Age 7 years or older
• Scheduled for a clinical abdominal MRI exam
• Exclusion Criteria:
• Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
• Sedation required for MRI
• Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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