Carbon Dioxide (CO2) and Cognitive Impairment

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.

Key facts

Study ID

NCT05292378

Run by

Rutgers, The State University of New Jersey

People needed

27

Starts

2022-07-14

Expected to finish

2025-03-20

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• History of COVID-19 vaccination
• Weigh at least 110 pounds

You may not qualify if…

• Colorblindness
• Inability to hear verbal instructions
• Cardiovascular disease, including a history of stroke
• Diabetes requiring the use of insulin
• Pregnancy
• Current asthma (an asthma attack within the past five years)
• Medications for or history of anxiety disorder diagnosis or panic attacks
• Medications which may affect cognition such as beta-blockers and CNS depressants
• Temporary Exclusion Criteria
• Respiratory symptoms in the previous four weeks
• Use of sedating cold/allergy medications in the previous week
• Use of marijuana in the previous week
• Consumption of alcohol in the previous 24 hours
• Additional Exclusion Criteria for Subjects undergoing the fMRI scan:
• History of head trauma or neurosurgery or neurological disorder
• Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
• Surgical pins or plates above the neck
• History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask
• Lead or iron tatoos
• Claustrophobia
• Back problems that would prevent the subject from laying still comfortably for up to 90 minutes
• Additional Exclusion Criteria for Subjects undergoing CAIM
• Current or recent contact lens use

Where it is running

• Rutgers - EOHSI — Piscataway, New Jersey, United States

Full record on ClinicalTrials.gov

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