Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children

Running, not enrolling

Conditions studied: Multisystem Inflammatory Syndrome in Children (MIS-C)

In brief

Multi-system Inflammatory Syndrome in Children (MIS-C) is a new condition related to COVID-19, the study investigators are still learning about its causes, effects, and long-term impact. "Long-Term Outcomes after the Multisystem Inflammatory Syndrome In Children", the Coronavirus MUSIC Study, is a research study funded by NIH and the National Heart, Lung, and Blood Institute. The study investigators hope to enroll at least 900 young people with MIS-C at children's medical centers in the U.S. and Canada. This research study will help us learn more about MIS-C and its effects on the long-term health of children.

Key facts

Study ID

NCT05287412

Run by

Carelon Research

People needed

1200

Starts

2020-09-30

Expected to finish

2026-07-31

Last updated by the study team

2026-03-27

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age <21 years.
• Fever ≥38°C for ≥24 hours, or report of subjective fever lasting ≥24 hours.
• Laboratory evidence of inflammation, including, but not limited to, one or more of the following: an elevated CRP, ESR, fibrinogen, procalcitonin, d-dimer, ferritin, LDH, or IL-6, elevated neutrophils, reduced lymphocytes and low albumin.
• Evidence of clinically severe illness requiring hospitalization, with multisystem (≥2) organ involvement, based on clinical judgment from record review, discharge diagnosis, laboratory or diagnostic tests. Organ system involvement includes but is not limited to cardiac, renal, respiratory, hematologic including coagulopathy, gastrointestinal including liver, dermatologic or neurological.
• Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms

You may not qualify if…

• No plausible alternative diagnosis, such as bacterial sepsis, murine typhus, staphylococcal or streptococcal shock syndromes

Where it is running

• University of Alabama — Tuscaloosa, Alabama, United States
• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Valley Children's Healthcare and Hospital — Madera, California, United States
• UC San Diego, Rady Children's Hospital — San Diego, California, United States
• Children's Hospital of Colorado — Aurora, Colorado, United States
• The Nemours Foundation — Wilmington, Delaware, United States
• Children's National Hospital — Washington D.C., District of Columbia, United States
• Joe DiMaggio Children's Hospital — Hollywood, Florida, United States
• Nicklaus Children's Hospital — Miami, Florida, United States
• Chldren's Healthcare of Atlanta — Atlanta, Georgia, United States
• Ann & Robert Lurid Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Children's Hospital — Indianapolis, Indiana, United States
• Children's Hospital of New Orleans — New Orleans, Louisiana, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• CS Mott Children's Hospital/University of Michigan — Ann Arbor, Michigan, United States
• Children's Hospital of Michigan — Detroit, Michigan, United States
• University of Mississippi — Jackson, Mississippi, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Morgan Stanley Children's Hospital of New York — New York, New York, United States
• Cohen Children's Medical Center — Queens, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• Duke Children's Hospital and Health Center — Durham, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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