3D PET Myocardial Blood Flow and Rb82 Infusion Profiles

Completed · Phase 4

Conditions studied: Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease, Cardiac Risk Factors, Myocardial Infarction

In brief

The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.

Key facts

Study ID

NCT05286593

Run by

Ochsner Health System

People needed

98

Starts

2021-12-28

Expected to finish

2022-09-30

Last updated by the study team

2023-01-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal Volunteers
• Adults ≥18 and <40 years old able to give informed consent.
• Ability to abstain from caffeine for 48 hours
• The "clinical" population
• Adults ≥18 years old able to give informed consent.
• Any cardiac risk factor including hypertension, hyperlipidemia, diabetes mellitus or tobacco use OR
• CAD defined by with history of PCI or CABG, Coronary Ca score>400, or dense coronary calcifications noted on chest CT
• Ability to abstain from caffeine for 48 hours
• The "infarct" population
• Adults ≥18 years old able to give informed consent.
• Prior cardiac PET scan demonstrating a fixed defect ≥ 15% of the LV myocardium with relative uptake ≤60% maximum uptake.
• In addition, to the perfusion defect, each volunteer requires either:
• FDG PET or MRI viability studies confirming infarct OR
• akinesis and wall thinning on ECHO within the same territory as the PET defect in addition to Q-waves on ECG
• Ability to abstain from caffeine for 48 hours

You may not qualify if…

• Normal Volunteers
• Any chronic cardiac disease or condition (e.g., hypertension, hyperlipidemia)
• Any chronic systemic disease or condition (e.g., diabetes, systemic lupus, rheumatoid arthritis)
• Tobacco use
• Family history in a first degree relative with clinical CAD (h/o PCI, MI or CABG) in men <55 or women <65
• Severe claustrophobia
• Positive urine pregnancy test
• Inability to give informed consent
• BMI ≥ 30 or BMI>25 and <30 provided waist to hip ratio >0.80 in women or 0.90 in men.
• The "clinical" and "infarct" populations
• Severe claustrophobia
• Hemodynamic instability or unstable symptoms
• Positive urine pregnancy test
• Inability to give informed consent

Where it is running

• Ochsner — New Orleans, Louisiana, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.