EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
Running, not enrolling · Phase 4
Conditions studied: Cardiovascular Disease, Myocardial Infarction, Stroke, Coronary Revascularization
In brief
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction \[NSTEMI\] and ST-segment elevation myocardial infarction \[STEMI\]).
Key facts
- Study ID
- NCT05284747
- Run by
- Amgen
- People needed
- 6019
- Starts
- 2022-10-26
- Expected to finish
- 2027-05-29
- Last updated by the study team
- 2025-10-06
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age greater than or equal to 18 years
- Hospitalized for primary reason of NSTEMI or STEMI due to presumed atherosclerotic disease
You may not qualify if…
- Participants requiring invasive hemodynamic and/or vasopressor/inotropic support at the time of screening
- Participants with elevated biomarkers of myocardial injury due to secondary/nonatherosclerotic etiology (eg, sepsis, atrial fibrillation, vasospasm, decompensated heart failure, uncontrolled hypertension, stress induced cardiomyopathy)
Where it is running
- Eastern Shore Research Institute — Fairhope, Alabama, United States
- Heart Center Research LLC — Huntsville, Alabama, United States
- Northern Arizona Healthcare Corporation Cardiovascular Institute — Flagstaff, Arizona, United States
- Scottsdale Healthcare at Shea - HonorHealth — Scottsdale, Arizona, United States
- Pima Heart and Vascular Clinical Research — Tucson, Arizona, United States
- John Muir Health and Cardiovascular Institute — Concord, California, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
- University of California Los Angeles — Los Angeles, California, United States
- University of California-Irvine — Orange, California, United States
- University of Colorado Hospital — Aurora, Colorado, United States
- Bridgeport Hospital — Bridgeport, Connecticut, United States
- Hartford Hospital — Hartford, Connecticut, United States
- Cardiology Associates of Fairfield County PC — Stamford, Connecticut, United States
- Excel Medical Clinical Trials — Boca Raton, Florida, United States
- Clearwater Cardiovascular Consultants — Clearwater, Florida, United States
- University of Florida at Gainesville — Gainesville, Florida, United States
- University of Florida and Shands Hospital — Jacksonville, Florida, United States
- AdventHealth Orlando — Orlando, Florida, United States
- Cardiology Partners Clinical Research Institute — Palm Beach Gardens, Florida, United States
- Baptist Health Care — Pensacola, Florida, United States
- Ascension Sacred Heart — Pensacola, Florida, United States
- Clearwater Cardiovascular Consultants — Safety Harbor, Florida, United States
- Tampa Cardiovascular Interventions and Research — Tampa, Florida, United States
- Clinical Site Partners Orlando dba Flourish Research — Winter Park, Florida, United States
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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