Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
Recruiting now
Conditions studied: Periprosthetic Joint Infection, Anti-Bacterial Agents
In brief
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery. Eligible patients will be included in this study after signing the informed consent form. After the second stage revision, according to the patient's symptoms and examination results, the attending physician used a reasonable antibiotic treatment scheme (including intravenous and oral medication). All patients voluntarily participated in the study and signed informed consent. During the treatment period, all prospective patients underwent clinical evaluation at the time points of 1, 3, 6, 12, 18 and 24 months after the start of antibiotic treatment after phase II revision. The infection control rate of patients was evaluated by follow-up at least 2 years after operation, so as to analyze the effect of antibiotic treatment course after two-stage revision of periprosthetic joint infection.
Key facts
- Study ID
- NCT05284318
- Run by
- First Affiliated Hospital of Fujian Medical University
- People needed
- 500
- Starts
- 2021-12-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2022-03-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1. A diagnosis of PJI was made according to MSIS criteria. 2. Received spacer implantation and a full course of antibiotic treatment (at least 6 weeks), the patient was clinically determined to have infection control and underwent secondary joint revision.
- Age ≥18 years old. 4. The patient voluntarily participated in the study, and was physically and mentally tolerant to the treatment process and various tests of the study. He has signed an informed consent form and passed the examination of all the hospital ethics committees participating in the study.
You may not qualify if…
- 1. Follow-up data not available. 2. Researchers judge that patients no longer meet the standards of the study due to compliance problems
Where it is running
- The First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (enrolling)
Full record on ClinicalTrials.gov
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