Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History.

Status unconfirmed

Conditions studied: Desmoid, Desmoid; Abdominal, Pregnancy Loss, Pregnancy Complications

In brief

Desmoid tumors (DT) are rare disease of intermediate malignancy with variable and often unpredictable clinical course. There is a growing interest in defining potential risk of recurrence or progression during or after pregnancy and in identifying potential obstetrical risks and infertility rate of desmoid patients. Aim of the study: * to define the impact of pregnancy on diagnosis, progression and recurrence of DT; * to define the risks related to DT of obstetrical risks and decisions to interrupt or avoid pregnancy after the diagnosis of DT.

Key facts

Study ID

NCT05284305

Run by

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

People needed

400

Starts

2022-03-01

Expected to finish

2023-05-15

Last updated by the study team

2023-01-27

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• histologically-proven DT;
• female patients
• fertile age, >18 years;
• concomitant or subsequent pregnancy (study group), or no history of pregnancy (screening group).

You may not qualify if…

• suspected DT without histological diagnosis • male patients affected by DT
• <18 years old, and non-fertile age.

Where it is running

• Mount Sinai Hospital/Toronto University — Toronto, Canada (enrolling)
• Desmoid Foundation Italy — Milan, Italy (enrolling)
• Brigham and Women Hospital / Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Istituto Oncologico Veneto IRCSS — Padova, Italy
• University of Padova — Padova, Italy
• Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Italy
• Institut Curie — Paris, France

Full record on ClinicalTrials.gov

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