Prevention of Broncho-aspiration (BA) in Adult Subjects During Their ICU Stay

Completed · Not applicable

Conditions studied: Bronchial Aspiration

In brief

Patients of age \>18 yo, admitted to the ICU through the surgery department from 2AUG2021 to 1AUG2022 will be divided into three groups: 1. Patients admitted to the ICU in the first 3-4 months will have their bed head elevated to 15 degrees + H2 blockers administration + mouth wash BID 2. Patients admitted to the ICU in the following 3-4 months will have their bed head elevated to 30 degrees + H2 blockers administration + mouth wash BID 3. Patients admitted in the last 3-4 months will have their bed head elevated to 45 degrees + H2 blockers administration + mouth wash BID. All patients will have their vital signs, BMI, and fluids ins and outs measured every 24 hours until the discharge from the ICU or death. All patients will be evaluated for GI functions (no vomiting, flatus+, bowel movement +, bowel sounds+, and KUB with normal gas distribution pattern) prior to oral intake. Patients in the three groups will be matched by age, sex, and BMI with historical controls with broncho- aspiration (BA) (positive controls) and without BA events (negative controls) from a pool of 20,032 ICU admissions (01JAN2010 to 31DEC2019).

Key facts

Study ID

NCT05284084

Run by

Marshall University

People needed

159

Starts

2021-08-03

Expected to finish

2021-11-02

Last updated by the study team

2023-04-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age>18
• All the patients admitted to ICU by surgery department.
• Development of aspiration pneumonia in patients admitted to ICU department of VA hospital.
• Aspiration Pneumonia development during hospital stay and treating physician indicated the diagnosis of aspiration pneumonia in history and physical exam notes.

You may not qualify if…

• Age <18
• Patient transferred or admitted to the hospital as a primary diagnosis of aspiration pneumonia (development of aspiration pneumonia prior to admission).
• Treating physician not documented aspiration pneumonia in history or physical exam notes.
• Drug overdose, seizure or cardiopulmonary arrest prior to hospital admission.

Where it is running

• Marshall University School of Medicine — Huntington, West Virginia, United States

Full record on ClinicalTrials.gov

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