Cannabidiol Effects on Learning and Anxiety

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Anxiety and Fear

In brief

To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut. All participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. The other face never is paired with a shock. After everybody learns this, half of the participants will receive 600 mg CBD Isolate Gel Capsules one time, and the other half will receive a placebo dose. Participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. It is hypothesized that participants that receive CBD will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.

Key facts

Study ID

NCT05283382

Run by

University of Connecticut

People needed

160

Starts

2024-10-30

Expected to finish

2027-02-01

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-50 years of age

You may not qualify if…

• Difficulties seeing a computer screen
• Anyone currently taking CBD within the last 24 hours.
• Anyone using any cannabis product within the last 24 hours.
• Heart problems or heart disease
• A neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm
• Are currently pregnant or breast-feeding

Where it is running

• University of Connecticut — Storrs, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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