Neurophysiological Mechanisms of Language Comprehension
Recruiting now · Not applicable
Conditions studied: Language Disorders
In brief
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes that are implanted for clinical purposes (see subject populations). At the end of the sentence, the subjects have to indicate how they comprehended the sentence by selecting which of several pictures matches the sentence they just read. Behavioral measures that the investigators record and analyze are their response times to advance to each next word in the sentence, and which picture they chose for each sentence. These behavioral measures are compared against the neural activity simultaneously recorded as they are made. Then, in a later session, the same participants will participate in a task-related stimulation experiment. This follows the exact same design as the recording-only reading experiment, the only difference is that on some trials, at controlled moments during the sentence presentation intracranial electrical stimulation is delivered through adjacent intracranial electrode contacts. The investigators will examine the effect of this stimulation on the subjects comprehension of the sentences measured by their behavior, and on the simultaneously recorded neural activity.
Key facts
- Study ID
- NCT05283265
- Run by
- University of Alabama at Birmingham
- People needed
- 153
- Starts
- 2022-04-08
- Expected to finish
- 2026-10-08
- Last updated by the study team
- 2026-03-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 and older
- Undergoing standard of care stereo Electro Encephalogram (sEEG) or Electro-Corticogram (ECoG) monitoring
- Able to competently perform control trials of the task
You may not qualify if…
- Age less than 18 years
- Unable to competently perform control trials of the task
Where it is running
- The University of Alabama at Birmingham Hospital — Birmingham, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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