A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas

Recruiting now · Phase 1

Conditions studied: Advanced Solid Tumor, Advanced Lymphoma

In brief

This is a first-in-human (FIH) study to evaluate the safety and preliminary efficacy of experimental drug CS5001 used as a single agent and in combination with systemic therapies in patients with advanced hematological and solid tumors.

Key facts

Study ID

NCT05279300

Run by

CStone Pharmaceuticals

People needed

480

Starts

2022-03-28

Expected to finish

2027-12-31

Last updated by the study team

2025-08-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For solid tumor patients of dose escalation, they must have pathologically confirmed, unresectable advanced solid tumor with disease progression on or after at least 1 line of prior systemic therapy.
• For Lymphoma patients of dose escalation, they must have pathologically confirmed Hodgkin and non-Hodgkin B-cell lymphoma as defined per 2016 World Health Organization(WHO) classification, with disease progression on or after at least 2 lines of prior systemic therapy.
• For mono-therapy cohorts, eligible patients must have pathologically confirmed relapsed/refractory (R/R) lymphomas or advanced solid tumors, and have demonstrated failure with previous line(s) of standard-of-care treatment. Patients in the solid tumor cohort must exhibit ROR1-positive expression in their baseline tumor tissues. For combination therapy cohorts, DLBCL patients must either be treatment-naïve or have experienced failure with at least one prior line of standard-of-care therapy to qualify for treatment with CS5001 in combination with first-line or subsequent standard-of-care therapies for DLBCL. Solid tumor patients must have pathologically confirmed disease, be naïve to PD-1/PD-L1 inhibitors, and have at least failed first-line therapy or standard-of-care treatment.
• For dose escalation, with at least one evaluable lesion as defined per Response Evaluation Criteria in Solid Tumours(RECIST) v1.1 solid tumor or per 2014 Lugano Classification Criteria for lymphoma, respectively. For dose expansion, with at least one measurable lesion as defined per RECIST v1.1 solid tumor or per 2014 Lugano Classification Criteria for lymphoma, respectively.
• Life expectancy > 3 months.
• Eastern Cooperative Oncology Group(ECOG) performance status 0-2.
• Have adequate organ function.

You may not qualify if…

• Has disease that is suitable for local treatment administered with curative intent. For lymphoma, candidacy for hematopoietic stem cell transplantation based on the Investigator's judgment.
• Has a history of a second malignancy active within the previous 3 years except for locally curable cancers that have been apparently cured.
• For dose expansion: Participation in other studies involving therapies targeting ROR1 prior to study entry and/or during study participation.
• Has known central nervous system (CNS) lymphoma or solid tumor CNS metastasis that is either symptomatic, untreated, or requires therapy.
• Has other acute or chronic medical or psychiatric conditions.
• Has a diagnosis of immunodeficiency, or has an active autoimmune disease or other conditions that require systemic steroid therapy.
• Has peripheral edema, pericardial effusion, or ascites indicated for medical intervention or limiting activity of daily life. Or with a known history of peripheral vasculopathies.
• Patients with any active infections requiring systemic therapy within 2 weeks prior to the administration of the first dose of the study drug.
• Patients known to be human immunodeficiency virus (HIV)-positive or have acquired immune deficiency syndrome (AIDS).
• Significant cardiovascular disease within 6 months prior to the first dose of the study drug.
• Significant screening electrocardiogram (ECG) abnormalities.
• Has received major surgery, chemotherapy, definitive radiotherapy, target therapy, immunotherapy, or other anti-cancer therapy within 21 days prior to the administration of the first dose of the study drug.
• Administration of a live vaccine within 28 days prior to the administration of the first dose of the study drug.
• Has active graft versus host disease.
• With known active alcohol or drug abuse.
• Women who are pregnant or breastfeeding.

Where it is running

• First Affiliated Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (enrolling)
• Columbia U. - Herbert Irving Comprehensive Cancer Center — New York, New York, United States (enrolling)
• BUMC - Mary Crowley Cancer Research Centers (MCCRC) — Dallas, Texas, United States (enrolling)
• Scientia Clinical Research Limited — Randwick, New South Wales, Australia (enrolling)
• Epworth Freemasons Medical Centre — East Melbourne, Victoria, Australia (enrolling)
• Beijing Cancer Hospital — Beijing, Beijing Municipality, China (enrolling)
• The Cancer Hospital Affiliated to Chongqing University — Chongqing, Chongqing Municipality, China (enrolling)
• Guangdong Province Hospital — Guangzhou, Guangdong, China (enrolling)
• Guangxi Medical University Affiliated Tumour Hospital — Nanning, Guangxi, China (enrolling)
• The Fourth Hospital of Hebei Medical University — Shijiazhuang, Hebei, China (enrolling)
• Henan Cancer Hospital — Zhengzhou, Henan, China (enrolling)
• Hubei Cancer Hospital — Wuhan, Hubei, China (enrolling)
• Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• The First Affiliated Hospital of Soochow University — Suzhu, Jiangsu, China (enrolling)
• The Second Hospital of Dalian Medical University — Dalian, Liaoning, China (enrolling)
• Shandong Cancer Hospital — Jinan, Shandong, China (enrolling)
• Fudan University Shanghai Cancer Hospital — Shanghai, Shanghai Municipality, China (enrolling)
• Shanghai East Hospital — Shanghai, Shanghai Municipality, China (enrolling)
• Institute of Hematology & Blood Diseases Hospital — Tianjin, Tianjin Municipality, China (enrolling)
• North Shore Hematology Oncology Associates — East Setauket, New York, United States (enrolling)
• Central Adelaide Local Health Network Incorporated — Adelaide, South Australia, Australia (enrolling)
• Royal Adelaide Hospital (RAH) — Adelaide, South Australia, Australia (enrolling)
• Ashford Cancer Centre Research — Adelaide, South Australia, Australia
• Yunnan Cancer Hospital — Kunming, Yunnan, China
• Henan Provincial People's Hospital — Zhengzhou, Henan, China

Full record on ClinicalTrials.gov

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