E-cigarettes for Harm Reduction in Adults With Asthma

Completed · Not applicable

Conditions studied: Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking

In brief

Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma. However, little is known about the effects on smoking and lung health of substituting cigarettes with ENDS in adults with asthma. This project aims to test whether providing ENDS to adults with asthma will lead to substitution of smoking for ENDS, reduced dependence, and improved lung function so such knowledge can inform interventions to reduce the public health burden of tobacco.

Key facts

Study ID

NCT05278065

Run by

Brown University

People needed

17

Starts

2022-05-01

Expected to finish

2024-09-12

Last updated by the study team

2025-11-18

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (50%), 21 to 65 (inclusive) years of age;
• Persistent asthma symptoms (i.e., episodic symptoms of airflow obstruction / airway hyperresponsiveness (AHR) as documented in review of medical history);
• Currently prescribed SABA medication;
• Past-year smoking of ≥5 cigarettes/day;
• Exhaled CO ≥ 6 ppm at baseline;
• Zero breath alcohol during informed consent for participation;
• English-speaking at an 8th grade level.

You may not qualify if…

• Intention to quit smoking during the next 30 days;
• Current engagement in any smoking cessation treatment;
• Current self-identification as regular ENDS user or using ENDS > 2 days / week;
• Medical contraindication to nicotine;
• Pregnancy (due to toxicity of nicotine and tobacco products);
• Current alcohol dependence (AUDIT > 15)
• Urine-screened or past-month self-reported use of illicit substances (amphetamine, cocaine, methamphetamine, opioids, benzodiazepines);
• Current psychosis, mania, or suicidal ideation;

Where it is running

• Center for Alcohol and Addiction Studies — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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