Neuroplasticity After Proprioceptive Rehabiliation

Recruiting now

Conditions studied: Stroke, Hemiparesis, Traumatic Brain Injury

In brief

Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances neuroplasticity. The aim of the research is to study the activity in cerebrospinal circuitry to evaluate the neuroplastic changes during and after instrumented proprioceptive rehabilitation relying on sequences of muscle vibration in subacute stroke stages.

Key facts

Study ID: NCT05277519
Run by: Institut National de la Santé Et de la Recherche Médicale, France
People needed: 56
Starts: 2022-06-16
Expected to finish: 2027-12-15
Last updated by the study team: 2026-07-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

hemiparesis at least transient in lower limb following an acquired brain injury (stroke or traumatic brain injury)
French spoken
Affiliated to a French social insurance
No previous traumatic, vascular or neurodegenerative injuries
Having presented during the acute phase or presenting a motor deficit of one of the lower limbs
Presenting an absence of autonomy of walking at the entrance of the rehabilitation department
In the sub-acute phase, i.e. from 15 days to 6 months after the accident
Presenting moderate cognitive disorders allowing them to understand instructions and give their consent

You may not qualify if…

strong cognitive disorders
maintenance of justice, tutelage, legal guardianship
Pregnancy and breastfeeding
Outpatients who do not have weekly follow-up in the rehabilitation department

Where it is running

Pitié-Salpêtrière Hospital — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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