The Electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment

Running, not enrolling · Not applicable

Conditions studied: Genetic Disease

In brief

The eMERGE Network embraces the opportunity to use new methods in genomic medicine, information science, and research participant engagement to identify people at very high risk for specific diseases and recommend individualized approaches to prevention and care. The investigators will conduct a prospective study, with diverse and underserved participants, across ten eMERGE study sites to evaluate clinical implementation of a Genome Informed Risk Assessment (GIRA) tool that combines genetic, family history, and clinical risk information from participants.

Key facts

Study ID

NCT05277116

Run by

Vanderbilt University Medical Center

People needed

26877

Starts

2022-02-16

Expected to finish

2026-12-31

Last updated by the study team

2025-08-29

Who can join

Age: 3 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults 18-75
• Children 3 to < 18
• Able to read or understand English or Spanish
• Able to provide a healthcare provider or clinician to receive results
• Willing to accept GIRA report

You may not qualify if…

• Inability to provide consent
• Transplant (solid organ or bone marrow) or transfusion within 8 weeks
• Research staff and investigators in eMERGE
• Not a patient at parent institution

Where it is running

• University of Alabama Birmingham — Birmingham, Alabama, United States
• Mountain Park Health Center — Tempe, Arizona, United States
• Northwestern — Chicago, Illinois, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Mount Sinai — New York, New York, United States
• Columbia University — New York, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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