Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Recruiting now

Conditions studied: Fibromyalgia, Rheumatoid Arthritis

In brief

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Key facts

Study ID

NCT05277025

Run by

University of Florida

People needed

150

Starts

2022-03-22

Expected to finish

2027-02-28

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 18-70
• Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
• Fulfills the 2010 ACR-EULAR classification criteria for RA
• Healthy volunteers: No significant pain/fatigue/depression/anxiety.

You may not qualify if…

• Diabetes
• Cancer
• Advanced liver, kidney or cardiovascular disease
• Neuropathic pain

Where it is running

• University of Florida — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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