Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms

Completed · Not applicable

Conditions studied: Light Exposure, Meal Timing

In brief

The aim of this study is to determine the principal time cue (light or meals) for resetting circadian rhythms in melatonin and metabolic outcomes.

Key facts

Study ID

NCT05276739

Run by

Brigham and Women's Hospital

People needed

47

Starts

2022-07-29

Expected to finish

2026-07-31

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged between 18-30 years
• Healthy (no medical, psychiatric or sleep disorders;
• Non-smoking for at least 6 months;
• Body Mass Index of >18 or <30 kg/m2;
• Able to maintain 8-hour consistent sleep schedule during the study
• Able to refrain from caffeine, alcohol, medication and supplements during the study

You may not qualify if…

• History of alcohol or substance abuse;
• Positive result on drugs of abuse urine toxicology;
• Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, narcolepsy, insomnia, or any significant sleep complaint
• Psychiatric disorder, or first degree relative with a psychiatric disorder
• Recent acute or chronic medical disorder
• Use of drugs or medication (birth control OK) likely to affect sleep, alertness or light sensitivity, as determined by the investigators
• Visual disorder, including but not limited to color blindness, or family history of glaucoma
• Pregnancy or lactation
• Shift work (past 3 years)
• Transmeridian travel (2 or more time zones) in the past 3 months
• Any other reason as determine by the Principal Investigator

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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