Role of Prophylactic Postoperative Antibiotics in HoLEP

Withdrawn before enrolling · Phase 4

Conditions studied: Benign Prostatic Hyperplasia, Urinary Tract Infections

In brief

The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection. The findings of this trial will have a major impact on clinical practice to either justify the prescription of antibiotics after HoLEP or give urologists more confidence in not prescribing antibiotics prophylactically after HoLEP.

Key facts

Study ID

NCT05274672

Run by

Baylor Research Institute

People needed

0

Starts

2023-03-01

Expected to finish

2025-02-20

Last updated by the study team

2026-02-12

Who can join

Age: 40 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Men > 40 years old with moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia (BPH).
• Patient with negative preoperative urine culture.

You may not qualify if…

• Patients with history of recurrent urinary tract infection or uro-sepsis.
• Patient with preoperative infections
• Patient with indwelling urethral catheter
• Patient doing continuous intermitted catheterization (CIC)

Where it is running

• Einstein Healthcare network — Philadelphia, Pennsylvania, United States
• Baylor Scott and White — Temple, Texas, United States

Full record on ClinicalTrials.gov

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