Predictors of Cognitive Outcomes in Geriatric Depression

Running, not enrolling · Phase 4

Conditions studied: Major Depressive Disorder, Neuroticism, Cognitive Change, Stress

In brief

This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.

Key facts

Study ID

NCT05273996

Run by

David Steffens

People needed

75

Starts

2021-09-28

Expected to finish

2027-04-30

Last updated by the study team

2026-05-22

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• major depression, single episode or recurrent;
• ability to read and write English;
• Mini-Mental State Examination >25.

You may not qualify if…

• lifetime alcohol/drug dependence
• conditions associated with brain abnormalities such hydrocephalus, benign and cancerous brain tumors, epilepsy, Parkinson's disease, Huntington's chorea, dementia, demyelinating diseases, etc.
• untreated endocrine disorder other than diabetes mellitus
• established clinical diagnosis of dementia
• other primary psychiatric disorders, e.g., panic disorder, social phobia, obsessive- compulsive disorder, schizoaffective disorder, schizophrenia, bipolar disorder

Where it is running

• UConn Health — Farmington, Connecticut, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.