Stimulation of the Larynx to Treat Unexplained Chronic Cough

Recruiting now · Not applicable

Conditions studied: Cough

In brief

Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.

Key facts

Study ID

NCT05273190

Run by

University of Minnesota

People needed

60

Starts

2021-07-13

Expected to finish

2027-06-30

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older, up to 88. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-88
• >8 weeks of cough
• Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale
• Ability to provide informed consent and independently complete questionnaires
• Ability to read and speak English

You may not qualify if…

• Electronic implants (e.g., pacemaker)
• Currently doing speech therapy for cough
• Contraindications to safe or effective VTS device use
• No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis)
• Untreated carotid disease
• BMI > 40 (for transmission of VTS through soft tissue)
• Current or recent (quit < 3 months ago) smoking
• Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
• History of known or suspected aspiration pneumonia
• Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD)
• Diagnosis or clinical suspicion of interstitial lung disease (ILD)
• Unmanaged reflux
• Unmanaged allergies/postnasal drip

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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