MOBility Disorders Assessment in Patients With Mild COGnitive Disorders

Recruiting now

Conditions studied: Cognitive Dysfunction

In brief

Mild cognitive impairment (MCI) is defined by lower performance in one or more cognitive domains with preservation of independence in functional abilities. Sixteen percent of community-dwelling older people (over 65 years) live with MCI. They are both cognitively and physically vulnerable. From a cognitive perspective, they are susceptible to converting to the dementia stage at an annual rate of 10%. From a physical perspective, the proportion of slow gait or neurological gait abnormalities can reach 46% in the population with MCI. Falls in turn increase the risk of accelerated cognitive decline and the risk of institutionalization. In the absence of a curative treatment for dementia, it is essential to have an effective and personalized prevention strategy by identifying the predictive factors for falls in this at-risk population with MCI. The research goals of this project are 1) to identify specific predictors for falls in clinic attendees with MCI in preparation for a definitive, fully powered study across France, and 2) to demonstrate the feasibility of a pragmatic fall risk assessment in MCs, whatever its setting and location. We aim to prospectively follow-up people diagnosed with MCI and aged above 65 years old in four MCs in France (three in the North (one community-based MC), and one in the Centre) for one year.

Key facts

Study ID

NCT05273125

Run by

University Hospital, Lille

People needed

417

Starts

2022-09-09

Expected to finish

2026-09-01

Last updated by the study team

2026-05-22

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient being diagnosed with MCI, according to the 2011 criteria
• Able to walk 4 meters with or without technical assistance
• Comprehension of French language allowing the realization of the neuropsychological assessment

You may not qualify if…

• Severe visual or hearing impairment that does not allow the assessment
• Severe pathology that makes follow-up impossible
• Administrative reasons: inability to receive informed information, inability to participate in the entire study, lack of social security insurance, refusal to sign consent form
• Under legal protection (guardianship, curatorship, safeguard of justice)

Where it is running

• Les Bateliers Chu Lille — Lille, France (enrolling)
• Hop Salengro - Hopital B — Lille, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.