Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Running, not enrolling · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Alzheimers Disease, Dementia, Alzheimers Disease, Familial

In brief

To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.

Key facts

Study ID
NCT05269394
Run by
Washington University School of Medicine
People needed
197
Starts
2021-12-22
Expected to finish
2028-07-01
Last updated by the study team
2026-07-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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