Ketamine and Kidney Injury in Cardiac Surgery
Running, not enrolling · Phase 4
Conditions studied: Cardiac Surgery
In brief
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
Key facts
- Study ID
- NCT05268562
- Run by
- Mayo Clinic
- People needed
- 200
- Starts
- 2022-03-02
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-07-13
Who can join
Age: 70 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
- Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).
You may not qualify if…
- Left or right ventricular assist device implantation or explantation.
- Procedures not requiring cardiopulmonary bypass.
- Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded).
- Severe hepatic disease resulting in ascites.
- Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis.
- Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months).
- Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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