CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Shock, Cardiogenic
In brief
The investigators are interested in determining if there is a meaningful benefit from the use of medications purported to increase the pumping function of the heart (i.e. inotropes) among critically ill patients admitted to the Cardiac Intensive Care Unit (CICU). To do this, the investigators will conduct a multi-centre, double blind, randomized control trial with patients who are deemed to require these medications by their treating physician to one of the two most commonly used agents in Canada (Milrinone or Dobutamine) or placebo. Each patient will be closely monitored by their healthcare team. The dose of medication will be adjusted according to each patients' clinical status. After 12 hours, the participants will move to open label treatment and any continued use of inotropes will be at the discretion of their treating physician.
Key facts
- Study ID
- NCT05267886
- Run by
- Ottawa Heart Institute Research Corporation
- People needed
- 346
- Starts
- 2022-03-05
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients ≥ 18 years of age admitted to an intensive care unit
- SCAI class C or D cardiogenic shock
You may not qualify if…
- Unwilling or unable to obtain informed consent by the participant or substitute decision maker
- Patients who are currently pregnant or breast-feeding
- Patients presenting with an out-of-hospital cardiac arrest (OHCA)
- Administration of milrinone or dobutamine in the 24 hours preceding anticipated randomization
- Severe obstructive valvular lesions, including aortic stenosis and/or mitral stenosis
- Dynamic left ventricular outflow tract obstruction
Where it is running
- Hamilton Health Sciences — Hamilton, Ontario, Canada (enrolling)
- University of Ottawa Heart Institute — Ottawa, Ontario, Canada (enrolling)
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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