Acupuncture vs Sham Acupuncture for Hand Osteoarthritis
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Hand Osteoarthritis
In brief
The investigators plan to conduct this multicentered, sham-controlled randomized clinical trial to evaluate the efficacy and safety of acupuncture for clinical symptomatic improvement of hand OA.
Key facts
- Study ID
- NCT05267093
- Run by
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
- People needed
- 340
- Starts
- 2022-04-26
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-07-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed as hand OA according to the American College of Rheumatology (ACR) clinical classification criteria
- History of hand OA for at least 3 months before enrollment and history of taking nonsteroidal anti-inflammatory drugs (NSAIDs) to treat hand OA
- Aged 18-80 years
- At least 40 mm in visual analog scale (VAS) on the average pain intensity of the dominant hand over the last 48 hours (patients applying NSAIDs at the screening have to have an increase in pain in the dominant hand of ≥ 20 mm after 1-week washout)
- Posterior-anterior radiographs of the dominant hand shows Kellgren-Lawrence grade 1, 2, or 3 changes in symptomatic joints
- Negative results in both rheumatoid factor and anticyclonic citrullinated peptide
- Able to comply with the study protocol and understand the medical information forms
- Voluntarily sign the informed consent
You may not qualify if…
- History or current evidence of secondary OA (due to causes other than a solely degenerative joint disease) or symptomatic OA at additional locations besides the hand(s) requiring treatment, or any painful syndrome of the upper limb which may interfere with evaluation of hand pain;
- History of inflammatory arthritis (such as rheumatoid arthritis (RA) or psoriatic arthritis), hemochromatosis, metabolic, or neuropathic arthropathies;
- History of trauma, dislocation or operation to the hand or arm in the previous 3 months;
- Hand pain and stiffness due to tissue scarring or tendinitis;
- Skin damage or serious skin disorders in the hands;
- Intake of antidepressants, anticonvulsants, vascular or narcotics during the 10 days prior to beginning the study;
- Oral, intramuscular, intra-articular or intravenous corticosteroids, or hyaluronic acid injection within 3 months preceding enrollment;
- Serious uncontrolled medical conditions such as cancer, uncontrolled cardiovascular disorder, severe hepatic/renal insufficiency or coagulation disorder;
- Known phobic to acupuncture or received acupuncture treatment within 4 weeks prior to enrollment.
Where it is running
- Department of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences Guang'anmen Hospital — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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