Mode of Exercise and Bone Biomarkers in Older Veterans

Recruiting now · Not applicable

Conditions studied: Aging, Musculoskeletal Diseases, Osteoporosis

In brief

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Key facts

Study ID: NCT05266976
Run by: VA Office of Research and Development
People needed: 120
Starts: 2022-07-06
Expected to finish: 2027-06-30
Last updated by the study team: 2026-05-22

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Healthy older (60+ y) Veteran women and men in the Denver Metro Area
Normally active (e.g., recreational cycling or walking exercise)

You may not qualify if…

Impaired renal function, defined as an eGRF of <60 mL/min/1.73m2
Hepatobiliary disease, defined as liver function tests (AST, ALT) >1.5 times the upper limit of normal
Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) <0.5 or >5.0 mU/L
Serum Ca <8.5 or >10.3 mg/dL
Serum 25(OH)D <20 ng/mL
Uncontrolled hypertension, defined as resting systolic blood pressure (BP) >150 mmHg or diastolic BP >90 mmHg;
History of type 1 or type 2 diabetes
Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist
Anemia, defined as a serum hemoglobin <12.1 g/dL for women and <14.3 g/dL for men
Fracture in the past 6 months
Current diagnosis or symptoms of COVID-19
In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider. Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider.

Where it is running

Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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