Safety and Preliminary Efficacy Trial of BNT142 in Patients With CLDN6-positive Solid Tumors
Stopped early · Phase 1/Phase 2
Conditions studied: Solid Tumor
In brief
This study is an open-label, multicenter, Phase I/IIa, dose escalation, safety, and pharmacokinetics (PK) study of BNT142 followed by expansion cohorts in patients with Claudin 6 (CLDN6)-positive advanced tumors.
Key facts
- Study ID
- NCT05262530
- Run by
- BioNTech SE
- People needed
- 73
- Starts
- 2022-03-22
- Expected to finish
- 2025-12-22
- Last updated by the study team
- 2026-04-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Maryland Medical Center — Baltimore, Maryland, United States
- Duke University Medical Center — Durham, North Carolina, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- South Texas Accelerated Research Therapeutics (START) - San Antonio — San Antonio, Texas, United States
- NEXT Virginia — Fairfax, Virginia, United States
- National University Cancer Institute - National University Hospital — Singapore, Singapore
- HM Nou Delfos General Hospital — Barcelona, Spain
- Hospital Universitario Vall D'Hebron — Barcelona, Spain
- MD Anderson Cancer Center — Madrid, Spain
- START Madrid-FJD Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
- Hospital Universitario 12 de Octubre - Centro de Actividades Ambulatorias — Madrid, Spain
- START Madrid CIOCC Hospital Universitario HM Sanchinarro — Madrid, Spain
- Hospital Universitario Virgen de la Victoria Campus Universitario de Teatinos — Málaga, Spain
- Cambridge University Hospitals NHS Foundation Trust — Cambridge, United Kingdom
- The Clatterbridge Cancer Centre NHS Foundation Trust — Liverpool, United Kingdom
- Hammersmith Hospital, Imperial College School Of Medicine - Imperial College Healthcare NHS Trust — London, United Kingdom
- Churchill Hospital - Oxford University Hospitals NHS Foundation Trust — Oxford, United Kingdom
Full record on ClinicalTrials.gov
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