Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)
Completed · Phase 2 · Has a placebo group
Conditions studied: Cocaine Use Disorder
In brief
This is an 8-week, double-blind, randomized placebo-controlled trial of the efficacy of a combination of extended-release naltrexone (XR-NTX) and extended-release buprenorphine (XR-BUP) compared to matched placebo injections (PBO-Inj) for the treatment of cocaine use disorder (CUD).
Key facts
- Study ID
- NCT05262270
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 427
- Starts
- 2023-04-18
- Expected to finish
- 2025-07-21
- Last updated by the study team
- 2025-10-21
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be 18 to 65 years of age;
- Be interested in reducing or stopping cocaine use.
- Be willing to comply with all study procedures and medication instructions.
You may not qualify if…
- Have any condition for which, in the opinion of the site investigator or designee, study participation would not be in their best interest or that could prevent, limit, or confound the protocol-specified assessments.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- UCLA Vine Street Clinic — Los Angeles, California, United States
- Center on Substance Use and Health (CSUH) — San Francisco, California, United States
- Cove Behavioral Health — Tampa, Florida, United States
- University of Illinois at Chicago — Chicago, Illinois, United States
- University of Chicago — Chicago, Illinois, United States
- Mountain Manor Treatment Center — Baltimore, Maryland, United States
- Berman Center for Outcomes and Clinical Research at Hennepin Healthcare — Minneapolis, Minnesota, United States
- Addictions Institute of Mount Sinai — New York, New York, United States
- UTSW Medical Center, Center for Depression Research and Clinical Care — Dallas, Texas, United States
- University of Texas Health San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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