Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Recruiting now
Conditions studied: Glioma, Glioneuronal Tumor, Choroid Plexus Tumor, Pineal Tumors, Germ Cell Tumor, Tumor of the Sellar Region, Diffuse Midline Glioma, H3 K27M-Mutant, Ependymoma, Embryonal Tumor, Pineal Tumor, Hemangiopericytoma, Hemangioblastoma, Melanocytic Tumor of CNS
In brief
Every new classification depends on its prognostic power and on the type of treatment given. With the rapid evolution of diagnostic methods and the advance in new treatments, there is much less reliable information available on how patients with newly defined brain tumour entities should be treated and what to expect from the current treatments. The goal is to determine whether the new 2021 WHO classification, based on cIMPACT-NOW recommendations, results in more homogeneous patient groups than the old 2016 classification. Furthermore, it will help derive provisional guidelines on how patients with these newly defined tumour entities are best treated. These recommendations will be based on the experience of EORTC investigators with chosen treatments and their experience as reported in this data collection report.
Key facts
- Study ID
- NCT05259605
- Run by
- European Organisation for Research and Treatment of Cancer - EORTC
- People needed
- 1650
- Starts
- 2023-03-21
- Expected to finish
- 2038-07-29
- Last updated by the study team
- 2025-12-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Innsbruck Universitaetsklinik — Innsbruck, Austria (enrolling)
- Universitaetsklinikum Wien - AKH unikliniken — Vienna, Austria (enrolling)
- Onze Lieve Vrouw Ziekenhuis — Aalst, Belgium (enrolling)
- Institut Jules Bordet — Anderlecht, Belgium (enrolling)
- Universitair Ziekenhuis Brussel — Brussels, Belgium (enrolling)
- C.H.U. Sart-Tilman — Liège, Belgium (enrolling)
- AZ Delta - Campus Rumbeke — Roeselare, Belgium (enrolling)
- CHU Lyon - Hopital neurologique Pierre Wertheimer — Lyon, France (enrolling)
- Hopital de La Timone — Marseille, France (enrolling)
- Hopital la Pitie-Salpetriere — Paris, France (enrolling)
- Knappschaft Krankenhaus Langendreer — Bochum, Germany (enrolling)
- Universitaetsklinikum Bonn — Bonn, Germany (enrolling)
- Universitaetsklinikum Koeln — Cologne, Germany (enrolling)
- Universitaetsklinikum - Essen — Essen, Germany (enrolling)
- University Hospital Frankfurt -Senckenberg Institute of Neurooncology — Frankfurt, Germany (enrolling)
- Universitaetsklinikum Jena — Jena, Germany (enrolling)
- Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie — Leipzig, Germany (enrolling)
- Universitaetsklinikum Regensburg — Regensburg, Germany (enrolling)
- Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A. — Athens, Greece (enrolling)
- Ospedale Bellaria-Bologna — Bologna, Italy (enrolling)
- Azienda Ospedaliero-Universitaria Careggi — Florence, Italy (enrolling)
- Istituto Neurologico Carlo Besta — Milan, Italy (enrolling)
- IRCCS Ospedale San Raffaele — Milan, Italy (enrolling)
- Istituto Oncologico Veneto — Padova, Italy (enrolling)
- IRCCS-Regina Elena National Cancer Center — Roma, Italy (enrolling)
Full record on ClinicalTrials.gov
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