ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery

Stopped early · Phase 1/Phase 2

Conditions studied: Surgery

In brief

This study is being done to compare 2 types of pain control methods and determine which is more effective postoperatively for laparoscopic colorectal surgery. Group 1 will receive an intrathecal (IT) injection in the back in which a small dose duramorph and bupivacaine will be placed into the spinal fluid. Group 2 will receive an erector spinae plane (ESP) block in which bupivacaine and decadron are injected near the nerves under a muscle in the back.

Key facts

Study ID

NCT05257941

Run by

Indiana University

People needed

116

Starts

2022-01-27

Expected to finish

2024-08-29

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing an elective laparoscopic colorectal procedure at Indiana University Hospital or Methodist Hospital
• ASA Class 1, 2, 3 (American Society of Anesthesiologists physical status classification system)
• Age 18 to 80 years (male or female)
• BMI < 40kg/m2
• Desires regional anesthesia for postoperative pain control

You may not qualify if…

• Any contraindication for neuraxial analgesia or ESP block procedure
• Contraindications for neuraxial analgesia include: Elevated intracranial pressure (except in cases of pseudo-tumor cerebri), infection at the site of injection, lack of consent from the patient, patient refusal, true allergy to any drug used in the spine, and uncorrected hypovolemia.
• Contraindications for ESP block procedure include: Infection at the site of injection, patient refusal, true allergy to any of the drugs used in the block, and lack of patient consent.
• Any patient undergoing a laparoscopic abdominoperineal resection.
• Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery.
• Known true allergy to the study medications (morphine, bupivacaine, decadron, Tylenol, Celebrex)
• Takes over 30 mg of oral morphine equivalents daily
• Any history of substance abuse in the past 6 months
• End stage liver disease, end stage renal disease
• Body weight of < 50 kg

Where it is running

• IU Health University Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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