Effect of Combination Non Steroidal Antiinflammatory Drugs and Narrowband UVB Treatment in Non-Photoadapters

Stopped early · Not applicable

Conditions studied: Vitiligo

In brief

Narrow band UVB phototherapy is the mainstay of therapy for vitiligo. However, about 1/3 of patients cannot respond to phototherapy. The objective of this study is to determine if the use of ibuprofen can induce non-photoadapters (patients who cannot tolerate increases in NBUVB past 400 mJ/cm2 after 12 sessions) to convert to photoadapters and tolerate raising NBUVB doses to therapeutic levels

Key facts

Study ID

NCT05256147

Run by

Henry Ford Health System

People needed

3

Starts

2015-08-01

Expected to finish

2016-05-24

Last updated by the study team

2022-02-25

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients should have a diagnosis of vitiligo.
• Patients who are identified as nonphotoadapters (those who cannot increase NBUVB dose past 400 mJ/cm2) will be recruited for the study

You may not qualify if…

• Patients with the daily ibuprofen use, history of renal disease, cardiac disease, gastric uler and bleeding disorder will be excluded from the study. Patients with a history of lupus erythematosus and other photosensitivity disorders will be excluded from the study.

Where it is running

• Henry Ford Dermatology — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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