Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
Completed · Not applicable · Has a placebo group
Conditions studied: Inflammation, Metabolic Disorder, Hypertriglyceridemia
In brief
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes. Inflammation plays both direct and indirect roles in the development of type 2 diabetes (T2D), atherogenic cardiovascular diseases, and other causes of morbidity and mortality. Aronia melanocarpa (Aronia berries) are rich in bioactive polyphenolic compounds, which have been shown to lower inflammation and favorably impact metabolism. However, there is tremendous inter-individual variability in the bioavailability of polyphenolics and production of bioactive phenolic metabolites in the colon that depends, at least in part, on digestive metabolism by the gut microbiota. Little is known about the complex interactions among the gut microbiome, anti-inflammatory food metabolomic signatures, and human inflammation phenotypes. This study will utilize a systems-level approach to disentangle these complex interactions. The specific study objectives are as follows: 1. to determine the impact of Aronia supplementation on inflammation, metabolic health, and gut microbiome composition 2. to determine the static and dynamic metabolomic signature of Aronia based on an Aronia supplementation period and responses to a high-fat meal challenge
Key facts
- Study ID
- NCT05255718
- Run by
- Montana State University
- People needed
- 13
- Starts
- 2019-04-27
- Expected to finish
- 2019-08-18
- Last updated by the study team
- 2024-03-13
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-60 years
You may not qualify if…
- Individuals who are pregnant or have other health conditions that might make it difficult to participate in the study, including heart disease, diabetes, and hypertension
- Individuals who are unwilling or unable to complete multiple venipuncture collections.
- Individuals who have food allergies or sensitivities to berry fruits
- Individuals unwilling or unable to avoid foods on provided food list for the duration of the supplementation period.
- Individuals who have food allergies or dietary restrictions to any of the foods being used, including wheat, dairy, or Aronia berries (chokeberries)
- Individuals taking blood pressure, lipid-lowering, or anti-inflammatory medications
- Individuals who have taken antibiotics in previous 90 days
- Individuals who have food allergy or intolerance to red food dye
Where it is running
- Nutrition Research Laboratory — Bozeman, Montana, United States
Full record on ClinicalTrials.gov
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