Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Recruiting now

Conditions studied: Gaucher Disease, Type 1, Healthy

In brief

Objective of the trial. To define a sub-population which is at increased risk of developing Parkinson, beyond the fact of carrying Gaucher; in this sub-population the investigators shall conduct a comprehensive evaluation that includes a variety of non-invasive tests, whose purpose is to evaluate the state of the pre- Parkinson's disease signs, signs which can appear, even twenty years before the appearance of the disease, and also to compare them to a group of diagnosed Gaucher patients and a group of healthy people who are not carriers of Gaucher disease. A group of those carriers will be available for trial or for treatment, if there will be a medicine for the prevention of the development of Parkinson, obtainable.

Key facts

Study ID

NCT05253560

Run by

Shaare Zedek Medical Center

People needed

600

Starts

2017-05-16

Expected to finish

2030-12-31

Last updated by the study team

2026-04-29

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing to participate

You may not qualify if…

• PD patients
• Dementia

Where it is running

• Michal Becker- Cohen — Jerusalem, Please Select..., Israel (enrolling)

Full record on ClinicalTrials.gov

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