Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma

Recruiting now · Phase 2

Conditions studied: Non-hodgkin Lymphoma, Hodgkin Lymphoma

In brief

The addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (CAYA) with mature B-cell non-Hodgkin lymphoma (MB-NHL) and classical Hodgkin lymphoma (cHL).

Key facts

Study ID

NCT05253495

Run by

New York Medical College

People needed

80

Starts

2022-02-01

Expected to finish

2028-06-30

Last updated by the study team

2025-06-13

Who can join

Age: 3 and older, up to 39. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed patients with histologically or cytologically proven newly diagnosed MB-NHL or cHL according to WHO Classification who meet the following criteria are eligible:
• COHORT I:
• Burkitt lymphoma (ICD-O 9687/3) Burkitt-like lymphoma with 11q aberration (ICD-O 9687/3) Diffuse large B-cell lymphoma, NOS (ICD-O 9680/3) High grade B-cell lymphoma (ICD-O 9680/3)
• COHORT Ia: stage III with LDH ≥ 2 ULN OR stage IV (5-24% bone marrow lymphoma infiltration) (GROUP B)61
• COHORT Ib: any CNS involvement and/or BM involvement (≥ 25% lymphoma cells) (GROUP C)61 OR patients with less than 20% tumor size reduction post chemotherapy with cyclophosphamide, dexamethasone, vincristine (DOC Reduction for Cohort Ia).
• COHORT II Classical Hodgkin lymphoma (ICD-O 9650/3, 9663/3, 9651/3, 9652/3, 9653/3)
• COHORT IIa: stage I-IIA with bulky ± E, I-IIB no bulky ± E, IIIA ± E (INTERMEDIATE RISK)
• COHORT IIb: stage IIB with bulky ± E, IIIA with bulky ± E, IIIB, IV (HIGH RISK)
• Adequate organ function

You may not qualify if…

• Primary mediastinal B-cell lymphoma (PMBL)
• T-cell/histiocyte-rich large B-cell lymphoma
• Gray zone lymphoma
• Follicular lymphoma
• Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
• Posttransplant lymphoproliferative lymphoma (PTLD)

Where it is running

• University of Flordia — Gainsville, Florida, United States (enrolling)
• New York Medical College — Vallhala, New York, United States (enrolling)
• University of Alabama — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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