NGS vs Culture Outcomes for Treatment of PJI

Status unconfirmed · Not applicable

Conditions studied: Prosthetic Joint Infection

In brief

This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.

Key facts

Study ID

NCT05247281

Run by

Center for Innovation and Research Organization

People needed

250

Starts

2022-09-21

Expected to finish

2025-05-01

Last updated by the study team

2023-11-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (age > 18 years)
• Undergoing single stage revision or 1st stage resection arthroplasty/spacer placement for PJI (ICM-positive) of the hip or knee
• Written informed consent

You may not qualify if…

• Ongoing participation in another clinical trial
• Megaprosthesis

Where it is running

• University of Southern California — Los Angeles, California, United States
• Cleveland Clinic Florida — Weston, Florida, United States
• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Columbia University — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• Northwell Health — Staten Island, New York, United States
• Cleveland Clinic Ohio — Cleveland, Ohio, United States
• Rothman Orthopaedic Institute — Philadelphia, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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