Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

Recruiting now

Conditions studied: Osteoporosis, Osteoarthritis, Hip, Hip Fractures, Clonal Hematopoiesis of Indeterminate Potential, Aging

In brief

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

Key facts

Study ID

NCT05246813

Run by

Imelda Hospital, Bonheiden

People needed

24

Starts

2022-02-11

Expected to finish

2030-12-31

Last updated by the study team

2026-03-25

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65 years and older

You may not qualify if…

• known haematological condition (myelodysplasia, leukemia, cancer)
• inability to provide written informed consent

Where it is running

• Imelda Hospital — Bonheiden, België, Belgium (enrolling)

Full record on ClinicalTrials.gov

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