Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia
Recruiting now
Conditions studied: Chronic Lymphocytic Leukemia, CLL, Progressive Chronic Lymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia, Relapsed Chronic Lymphocytic Leukemia
In brief
The purpose of this study is to collect medical informations and samples from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.
Key facts
- Study ID
- NCT05246345
- Run by
- University Hospital, Clermont-Ferrand
- People needed
- 50
- Starts
- 2022-03-07
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2024-01-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age greater than or equal to 18 years old;
- chronic lymphocytic leukemia diagnosis according to iwCLL criteria;
- refractory and/or relapsed disease during or after venetoclax treatment;
- tumor samples available.
- Relapse might be progressive chronic lymphocytic leukemia or transformation into Richter syndrome.
- Patients must be able to express their opposition to be enrolled in this study, if need be.
- Patients must be affiliated at the French Social Security system
You may not qualify if…
- Patients of their legal guardians refusing to participate
Where it is running
- CHU de Reims — Reims, France (enrolling)
- CHU de Besançon — Besançon, France
- Hopital AVICENNE — Bobigny, France
- CHU clermont-ferrand — Clermont-Ferrand, France
- CHU de Clermont Ferrand — Clermont-Ferrand, France
- CHU Grenoble — Grenoble, France
- CHRU de Lille — Lille, France
- Centre LEON BERARD — Lyon, France
- CHU de Montpellier — Montpellier, France
- CHU Nancy — Nancy, France
- Hopital Pitié Salpetrière — Paris, France
- Hopital Haut LEVEQUE — Pessac, France
- CHU d'Amiens — Amiens, France
- IUCT Oncopole — Toulouse, France
Full record on ClinicalTrials.gov
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