Clinical Decision Support for PrEP

Running, not enrolling · Not applicable

Conditions studied: HIV Infections, Preexposure Prophylaxis (PrEP)

In brief

Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the federal initiative to end the HIV epidemic. However, healthcare providers lack tools to identify patients who are at increased risk for HIV infection and thus likely to benefit from PrEP. This pilot study will test the hypothesis that an electronic health record (EHR)-based clinical decision support system that incorporates an HIV risk prediction model can help providers identify patients at increased risk for HIV infection and improve PrEP prescribing in safety-net community health centers. The clinical decision support system will be implemented in the EHR at 2-3intervention clinics, while 2 control clinics will receive standard of care. The primary outcome is PrEP prescriptions. Other key metrics of PrEP-related care to be assessed include medication persistence, adherence to monitoring guidelines for PrEP, and rates of HIV/STI testing and diagnoses. The expected outcome is the foundation for a large-scale cluster randomized trial to test whether EHR-based clinical decision support tools for PrEP can improve PrEP prescribing and prevent new HIV infections in a national network of community health centers.

Key facts

Study ID

NCT05245201

Run by

Harvard Pilgrim Health Care

People needed

4

Starts

2022-07-11

Expected to finish

2027-08-01

Last updated by the study team

2025-10-08

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Primary care providers at participating clinics who are licensed to prescribe PrEP

You may not qualify if…

• N/A

Where it is running

• Saban Community Clinic — Los Angeles, California, United States
• Roanoke Chowan Community Health Center — Ahoskie, North Carolina, United States
• Kintegra Health — Gastonia, North Carolina, United States

Full record on ClinicalTrials.gov

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