A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

Running, not enrolling · Phase 2 · Has a placebo group

Conditions studied: Crohn's Disease

In brief

The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.

Key facts

Study ID

NCT05242471

Run by

Janssen Research & Development, LLC

People needed

703

Starts

2022-07-22

Expected to finish

2029-11-05

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Crohn's disease (CD) for at least 3 months prior to baseline
• Confirmed diagnosis of moderate to severe CD as assessed by Crohn'

Where it is running

• Hopital Nord Marseille — Marseille, France
• University of Alabama Liver Center — Birmingham, Alabama, United States
• Del Sol Research Management, LLC — Tucson, Arizona, United States
• Moore Clinical Trials, LLC — Little Rock, Arkansas, United States
• Om Research LLC — Apple Valley, California, United States
• Valley Gastroenterology Medical Group — Arcadia, California, United States
• Southern California Research Center — Coronado, California, United States
• Desert Gastroenterology Associates — Lancaster, California, United States
• Cedars Sinai Medical Center — Los Angeles, California, United States
• UCLA — Los Angeles, California, United States
• Hoag Memorial Hospital — Newport Beach, California, United States
• UCI Irvine Medical Center — Orange, California, United States
• Medical Associates Research Group, Inc. — San Diego, California, United States
• University of California San Francisco — San Francisco, California, United States
• University of Colorado — Aurora, Colorado, United States
• Medical Research Center of Connecticut — Hamden, Connecticut, United States
• Yale University School Of Medicine — New Haven, Connecticut, United States
• MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
• Pioneer Research Solutions Inc. — Coconut Creek, Florida, United States
• Homestead Associates in Research Inc — Homestead, Florida, United States
• Osceola Mental Health D/B/A Park Place Behavioral Health Care — Kissimmee, Florida, United States
• Florida Research Center Inc. — Lakewood Rch, Florida, United States
• University of Miami Hospital — Miami, Florida, United States
• Gastroenterology Group Of Naples — Naples, Florida, United States
• CHU Grenoble — Grenoble, France

Full record on ClinicalTrials.gov

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