Real-World Evidence Registry to Assess Outcomes of Catheter Ablation for Atrial Fibrillation (DYNAMIC AF Registry)

Stopped early

Conditions studied: Atrial Fibrillation

In brief

DYNAMIC AF is an observational, prospective, multi-center, non-randomized registry designed to obtain real world clinical experience of radiofrequency (RF) ablation for the treatment of paroxysmal (PAF) and persistent (PsAF) atrial fibrillation ablation. Patient assessments will occur at pre- procedure, procedure, 12 weeks, 6 months and 1 year post ablation.

Key facts

Study ID

NCT05242250

Run by

Heart Rhythm Clinical and Research Solutions, LLC

People needed

392

Starts

2022-01-10

Expected to finish

2023-12-31

Last updated by the study team

2024-01-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with symptomatic, refractory or intolerant to at least one Class I or III AAD, paroxysmal atrial fibrillation (AF episode terminating spontaneously within 7 days) or symptomatic, refractory or intolerant to at least one Class I or III AAD, persistent AF (continuous AF sustained beyond 7-days and less than 1-year) who, in the opinion of the investigator, are candidates for ablation for AF. Refusal to take AADs for any reason is considered intolerant for the purposes of this protocol.
• Plans to undergo an RF catheter ablation procedure using an ablation catheter manufactured by Abbott
• De Novo ablation unless it is a repeat procedure for a subject whose index procedure is also included in the registry
• 18 years of age or older
• Able and willing to participate in baseline and follow up evaluations for the full length of the registry

You may not qualify if…

• Pregnant women
• Individual who cannot read or write, or those who cannot legally consent for themselves
• Participating in another clinical trial or has participated in a clinical trial within 30 days prior to screening that may interfere with this registry.
• Long-standing persistent AF (continuous AF sustained >=1 year)
• Previous left atrial surgery for atrial fibrillation
• Having a repeat ablation, unless the subject's index ablation procedure is also included in the registry
• In the opinion of the investigator, any known contraindication to an ablation procedure or to any device or drug required for use during an ablation procedure as assessed by the investigator

Where it is running

• Grandview Medical Center — Birmingham, Alabama, United States
• Luminis Health Anne Arundel Medical Center — Annapolis, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Penn Presbyterian Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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