A Randomized Trial of NSAID Dosing Strategies

Completed · Phase 4

Conditions studied: Musculoskeletal Pain, Acute Pain

In brief

This study will compare the efficacy of two different non-steroidal anti-inflammatory drugs (NSAIDs) ketorolac and ibuprofen for people with acute moderate or severe musculoskeletal pain. The investigators will also determine whether taking acetaminophen prior to the NSAID impacts efficacy

Key facts

Study ID

NCT05239767

Run by

Montefiore Medical Center

People needed

407

Starts

2022-06-01

Expected to finish

2023-04-24

Last updated by the study team

2023-08-15

Who can join

Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute musculoskeletal pain: Any pain attributable to muscles, bones, joints, tendons, ligaments or supporting structures, as determined by the clinical team, of 10 days duration or less. Prior to the onset of acute pain, patients cannot have experienced pain in the same body region during the prior six months
• Pain has to be described as moderate or severe, when the patient is asked if the pain is mild, moderate or severe in intensity

You may not qualify if…

• Contraindication to NSAIDs (allergy to NSAID or allergy to aspirin without history of tolerating NSAIDs, history of gastrointestinal bleeding, daily medication for gastritis or PUD, chronic kidney disease 2-5, heart failure)
• Contraindication to acetaminophen (hepatitis or cirrhosis)
• Use of an NSAID within the previous eight hours
• Use of acetaminophen within the previous eight hours
• Chronic pain, defined as any pain on >50% of days for at least 3 months prior to onset of acute pain
• Recurrent pain in the same body part as the presenting complaint

Where it is running

• Montefiore — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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