DirEct Versus VIdeo LaryngosCopE Trial

Completed · Not applicable

Conditions studied: Acute Respiratory Failure

In brief

Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States. Failure to intubate the trachea on the first attempt occurs in more than 10% of all tracheal intubation procedures performed in the emergency department (ED) and intensive care unit (ICU). Improving clinicians rate of intubation on the first attempt could reduce the risk of serious procedural complications. In current clinical practice, two classes of laryngoscopes are commonly used to help clinicians view the larynx while intubating the trachea: a video laryngoscope (equipped with a camera and a video screen) and a direct laryngoscope (not equipped with a camera or video screen). For nearly all laryngoscopy and intubation procedures performed in current clinical practice, clinicians use either a video or a direct laryngoscope. Prior research has shown that use of a video laryngoscope improves the operator's view of the larynx compared to a direct laryngoscope. Whether use of a video laryngoscope increases the likelihood of successful intubation on the first attempt remains uncertain. A better understanding of the comparative effectiveness of these two common, standard-of-care approaches to laryngoscopy and intubation could improve the care clinicians deliver and patient outcomes.

Key facts

Study ID

NCT05239195

Run by

Vanderbilt University Medical Center

People needed

1420

Starts

2022-03-19

Expected to finish

2022-12-16

Last updated by the study team

2024-08-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is located in a participating unit.
• Planned procedure is orotracheal intubation using a laryngoscope.
• Planned operator is a clinician expected to routinely perform tracheal intubation in the participating unit.

You may not qualify if…

• Patient is known to be less than 18 years old.
• Patient is known to be pregnant.
• Patient is known to be a prisoner.
• Immediate need for tracheal intubation precludes safe performance of study procedures.
• Operator has determined that use of a video laryngoscope or use of a direct laryngoscope is required or contraindicated for the optimal care of the patient.

Where it is running

• UAB Hospital — Birmingham, Alabama, United States
• University of Colorado Denver — Aurora, Colorado, United States
• Denver Health Medical Center — Denver, Colorado, United States
• Ochsner Medical Center | Ochsner Health System — New Orleans, Louisiana, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Hennepin County Medical Center — Minneapolis, Minnesota, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Brooke Army Medical Center — Fort Sam Houston, Texas, United States
• Baylor Scott & White Health — Temple, Texas, United States
• Harborview Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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