Multi Tumor-Associated Antigen-Specific T Lymphocytes to Treat Patients With High Risk Solid Tumors

Recruiting now · Phase 1

Conditions studied: Solid Tumor

In brief

This is an open-label phase I dose-escalation study to evaluate the safety of partially human leukocyte antigen (HLA)-matched multi tumor-associated antigen-specific T cell (TAA-T) therapy following lymphodepleting conditioning with or without local tumor ablation for pediatric and adult patients with high-risk solid tumors due to the presence of refractory, relapsed and/or minimal residual detectable disease following conventional therapy (e.g., chemotherapy, surgery, radiation, autologous stem cell transplant, or targeted therapy).

Key facts

Study ID

NCT05238792

Run by

Children's National Research Institute

People needed

24

Starts

2021-11-17

Expected to finish

2029-10-01

Last updated by the study team

2026-08-04

Who can join

Age: 1 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of high-risk solid tumors known to express at least 2 targeted antigens by either histology or historical reference: Ewing sarcoma, Wilms tumor, neuroblastoma, rhabdomyosarcoma, soft tissue sarcoma, and osteosarcoma.
• HLA type and match through at least one allele with antigen-specific activity.
• Following conventional therapy: refractory disease, residual detectable disease, or relapsed disease.
• Age >= 1 year and <70 years
• Patient or parent/guardian capable of providing informed consent.
• No systemic corticosteroid exposure within 1 week of initiating protocol treatment.
• Karnofsky/Lansky score of ≥50%.
• For participant with history of total body irradiation (TBI), radiation to thorax, or treatment with cardiotoxic chemotherapy (anthracycline or equivalent): Left ventricular ejection fraction (LVEF) >50% OR left ventricular fractional shortening (FS) >27% (may be performed within the last 12 months, and after completion of such treatment/s)
• Hemoglobin >7.0 g/dL (level can be achieved with transfusion).
• Direct bilirubin ≤2.5 mg/dL or 3x ULN (whichever is higher).
• Aspartate transaminase (AST)/Alanine transaminase (ALT) ≤5 x the upper limit of normal for age.
• Serum creatinine <1.0 mg/dL or 2x the upper limit of normal for age (whichever is higher).
• Pulse oximetry of >90% on room air.
• Respiratory rate:
• <30 breaths per minute for patients aged <18 years
• <25 breaths per minute for patients aged ≥18 years
• Respiratory rate may be repeated if initial value is thought to be temporarily abnormal. If repeated, 2 values should be obtained ≥30 minutes apart prior to protocol treatment to be eligible.
• Twelve (12) weeks post last radiation dose to the mediastinum/chest with resolution of any respiratory symptoms.
• Negative pregnancy test in female patient of childbearing potential.
• Agree to use contraceptive measures during study protocol participation through 6 months post final TAAT infusion (for FOCBP).
• Prior to cycle #1 only (requisite for receiving lymphodepleting chemotherapy):
• Absolute neutrophil count (ANC) >1000 /ul.
• Platelet count >75,000 /ul.

You may not qualify if…

• Patients with uncontrolled infections. Uncontrolled infections are defined as bacterial, fungal, or viral infections with either clinical signs of worsening despite standard therapy. Progressing infection is defined as hemodynamic instability, worsening physical signs, or radiographic findings attributable to infection. Persisting fever without other signs or symptoms will not be interpreted as progressing infection.
• For bacterial infections, patients must be receiving definitive therapy and have no signs of progressing infection within 7 days prior to protocol treatment.
• For fungal infections, patients must be receiving definitive systemic anti-fungal therapy and have no signs of progressing infection within 7 days prior to initiating protocol treatment.
• Patients who received ATG, Campath or other immunosuppressive T cell monoclonal antibodies within 28 days prior to initiating protocol treatment.
• Exposure to chemotherapy or immunomodulatory medications within the last 2 weeks prior to initiating protocol treatment.
• Pregnant or lactating females.

Where it is running

• Children's National Hospital — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.