Novel Brain Neurotechnology for Optimizing Precision Mirror Therapy in Stroke

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Cerebrovascular Accident

In brief

The primary aim of this project will be to determine the effects of the tRNS-augmented unilateral and bilateral MT, and their effects relative to the control interventions (sham tRNS with unilateral or bilateral MT) on restoring health outcomes including motor function, daily function, quality of life and self-efficacy, and motor control strategy as well as brain activities (electroencephalography, EEG) in stroke patients.

Key facts

Study ID

NCT05238272

Run by

Chang Gung Memorial Hospital

People needed

128

Starts

2022-03-01

Expected to finish

2026-12-31

Last updated by the study team

2022-02-14

Who can join

Age: 35 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 3 months onset from a first-ever unilateral stroke;
• an initial FMA scores between 18 to 56, indicating moderate to mild upper extremity motor impairment (Thielman, Kaminski, \& Gentile, 2008);
• age between 35 to 85;
• no excessive spasticity in any of the joints of the affected arm (shoulder, elbow, wrist and fingers);
• ability to follow instructions and perform tasks (Mini Mental State Examination scores ≥24);
• no participation in any neurorehabilitation experiments or drug clinical trials and
• willing to provide written informed consent.

You may not qualify if…

• contradiction to tRNS including a history of epilepsy, pregnant, having pacemakers and metallic implants in the neck and heads (Rossi, Hallett, Rossini, Pascual-Leone, \& Safety of, 2009);
• History of drug or alcohol abuse(Rossi et al., 2009);
• concomitant neurological conditions such as dementia, Parkinson's disease, brain tumor, brain injury and other brain diseases (such as intracranial hypertension or cerebral edema);
• Botulinum toxin injections 3 months before enrollment
• have unstable cardiovascular status such as uncontrolled hypertension or New York Heart Association (NYHA) Class III/IV heart failure or are not suitable for receiving tRNS by the physician's assessments.

Where it is running

• Chang Gung Memotial Hospital — Taoyuan, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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