In-Home Study With MiniMed™ 780G Pump Automated Control in Type 2-Evaluation of the AHCL System in Adults With Insulin-requiring Type 2 Diabetes

Completed · Not applicable

Conditions studied: Type 2 Diabetes Treated With Insulin

In brief

The objective of the study is to assess the safety and effectiveness of MiniMed™ 780G system in adult subjects with insulin-requiring type 2 diabetes in a home setting. The combined run-in period and study period will be approximately 135 days long.

Key facts

Study ID

NCT05238142

Run by

Medtronic MiniMed, Inc.

People needed

574

Starts

2022-02-25

Expected to finish

2025-01-11

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Is age 18 - 80 years at time of screening.
• Has a clinical diagnosis of type 2 diabetes for 2 years or more as determined via medical record or source documentation by an individual qualified to make a medical diagnosis.
• Is on MDI regimen (basal/bolus regimen with long-acting insulin and rapid-acting analogs), defined as greater than or equal to 2 injections per day for at least 3 months prior signing the informed consent, or CSII pump therapy with or without CGM. The investigator will use their discretion to verify that insulin requirements have been stable for the last 3 months prior to screening.
• Is able to comply with technology, according to Investigator's judgment
• Does not require a legally authorized representative to consent on their behalf due to mental or intellectual disability.
• Is willing to perform fingerstick blood glucose measurements as needed.
• Is willing to wear the system continuously throughout the study.
• Has a Glycosylated hemoglobin (HbA1c) of less than 10% (as processed by Central Lab) at time of screening visit.
• Note: All HbA1c blood specimens will be sent to and tested by a National Glycohemoglobin Standardization Program (NGSP) certified Central Laboratory. HbA1c testing must follow NGSP standards.
• Has thyroid-stimulating hormone (TSH) in the normal range OR if the TSH is out of normal reference range the Free T3 is below or within the lab's reference range and Free T4 is within the normal reference range.
• Is willing to upload data from the study pump, must have Internet access, and a computer system, or compatible smartphone that meets the requirements for uploading the study pump.
• Is willing to take one of the following insulins and can financially support the use of insulin preparations as required by the study:
• Humalog (insulin lispro injection)
• NovoLog/NovoRapid (insulin aspart injection)
• Admelog (insulin lispro injection)

You may not qualify if…

• Has a history of 2 or more episodes of severe hypoglycemia, which resulted in any the following during the 6 months prior to screening:
• Medical assistance (i.e., Paramedics, Emergency Room [ER] or Hospitalization)
• Coma
• Seizures
• Has been hospitalized or has visited the ER in the 6 months prior to screening resulting in a primary diagnosis of uncontrolled diabetes.
• Has had diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar syndrome (HHS) in the last 6 months prior to screening visit.
• Will not tolerate tape adhesive in the area of sensor placement as assessed by a qualified individual.
• Has any unresolved adverse skin condition in the area of sensor placement (e.g., psoriasis, dermatitis herpetiformis, rash, Staphylococcus infection) at time of screening.
• Has (Total Daily Dose) of less than 8 units or greater than 250 units at time of screening.
• Has positive GAD (Glutamic Acid Decarboxylase) Antibody test
• Is female of child-bearing potential and result of pregnancy test is positive at screening
• Is sexually active female of child-bearing potential and is not using a form of contraception deemed reliable by the investigator.
• Is female and plans to become pregnant during the course of the study.
• Is being treated for hyperthyroidism at time of screening.
• Has diagnosis of adrenal insufficiency at time of screening.
• Has taken any oral, injectable, or intravenous (IV) glucocorticoids within 8 weeks from time of screening visit, or plans to take any oral, injectable, or IV glucocorticoids during the course of the study.
• Note: Intra-articular injections to treat pain (e.g., joint pain, bursitis, etc.) are permitted
• Is using hydroxyurea at time of screening or plans to use it during the study.
• Is actively participating in an investigational study (drug or device) wherein he/she has received treatment from an investigational study drug or investigational study device in the last 2 weeks prior to screening.(Note: Did not apply to subjects who transitioned from Phase 1 to Phase 2)
• Is currently abusing illicit drugs.
• Is currently abusing marijuana.
• Is currently abusing prescription drugs.
• Is currently abusing alcohol.
• Has a history of visual impairment which would not allow subject to participate in the study and perform all study procedures safely, as determined by the investigator.
• Has elective surgery planned that requires general anesthesia during the course of the study.

Where it is running

• Medical Investigations — Little Rock, Arkansas, United States
• Headlands Research California LLC — Escondido, California, United States
• Loma Linda University Medical Center — Loma Linda, California, United States
• Hoag Hospital Newport Beach — Newport Beach, California, United States
• Mills-Peninsula Medical Center: Diabetes Research Institute — San Mateo, California, United States
• Sansum Diabetes Research Institute — Santa Barbara, California, United States
• East Coast Institute for Research — Jacksonville, Florida, United States
• USF Diabetes Center — Tampa, Florida, United States
• Atlanta Diabetes Associates — Atlanta, Georgia, United States
• East Coast Institute for Research — Canton, Georgia, United States
• East Coast Institute for Research — Macon, Georgia, United States
• Endocrine Research Solutions — Roswell, Georgia, United States
• Javara — Thomasville, Georgia, United States
• NorthShore University Health System — Skokie, Illinois, United States
• Iowa Diabetes Research — West Des Moines, Iowa, United States
• MedStar Good Samaritan Hospital — Baltimore, Maryland, United States
• Endocrine & Metabolic Consultants — Rockville, Maryland, United States
• Park Nicollet International Diabetes Center — Saint Louis Park, Minnesota, United States
• Bryan Health — Lincoln, Nebraska, United States
• Atlantic Health System — Morristown, New Jersey, United States
• NYC Research Inc — Long Island City, New York, United States
• Northwell Health Physician Partners Endocrinology — New York, New York, United States
• Physicians East — Greenville, North Carolina, United States
• Texas Diabetes and Endocrinology — Austin, Texas, United States
• Javara — Conroe, Texas, United States

Full record on ClinicalTrials.gov

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