MVA-BN-RSV Vaccine Trial

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Respiratory Syncytial Virus Infections

In brief

Phase 3 randomized, double blind study comparing recombinant MVA-BN-RSV vaccine vs placebo for efficacy and safety in adults \>=60 years of age

Key facts

Study ID

NCT05238025

Run by

Bavarian Nordic

People needed

20419

Starts

2022-04-19

Expected to finish

2023-09-01

Last updated by the study team

2024-10-31

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female subjects ≥60 years of age.
• Informed Consent signed by the subject.
• Subjects may have one or more chronic medical conditions e.g., mild to moderate underlying illnesses such as chronic cardiac diseases and chronic lung disease (asthma and chronic obstructive pulmonary disease [COPD]), congestive heart failure (CHF), hypertension, type 2 diabetes mellitus, hyperlipoproteinemia, or hypothyroidism, that is clinically stable as assessed by the investigator.
• Absence of known, current, and life-limiting diagnoses that render survival to completion of the protocol unlikely.
• Ability to comply with trial requirements, which necessitates access to transportation to on-site visits, including symptom visits for a nasopharyngeal swab.
• Willingness and ability to utilize an application on a personal device (i.e., smartphone, tablet, etc.) or a provisioned device to record solicited events and record all per protocol required data during the surveillance period.
• For women of childbearing potential (WOCBP), agreement to use an acceptable method of contraception during the trial and a negative urine pregnancy test within 24 hours prior to vaccination.

You may not qualify if…

• History of or current clinical manifestation of any serious medical condition that in the opinion of the investigator would compromise the safety of the subject, confound data interpretation, or would limit the subject's ability to complete the trial.
• History of or active autoimmune disease, including diabetes mellitus type I. Vitiligo or hypothyroidism requiring thyroid replacement therapy are not exclusions. Rheumatoid arthritis not requiring immunomodulatory and/or immunosuppressant treatment is not an exclusion.
• Known or suspected impairment of immunologic functions, including chronic inflammatory bowel disorders.
• Clinically significant mental disorder that would prevent patients from giving informed consent and complying with study procedures (e.g., completion of the electronic diary).
• Active or recent (within 6 months before enrollment) history of chronic alcohol abuse.
• History of a serious reaction to any prior vaccination or Guillain-Barré syndrome (GBS) within 6 weeks of any prior influenza immunization.
• History of allergic disease or reactions likely to be exacerbated by any component of the vaccine, e.g., tris(hydroxymethyl)-amino methane, chicken embryo fibroblast proteins, gentamycin, ciprofloxacin; this includes:
• Known allergy to eggs or aminoglycosides
• History of anaphylaxis or severe allergic reaction to any vaccine
• Any administration or planned administration of:
• A licensed live or vector-based vaccine within 30 days prior to or after trial vaccine administration.
• A licensed inactivated or ribonucleic acid (RNA)-based vaccine within 14 days prior to or after trial vaccine administration.
• Previous vaccination with an RSV vaccine, or any planned vaccination with an RSV vaccine other than the trial vaccine.
• Planned chronic, systemic administration (defined as more than 14 days) of >10 mg prednisone (or equivalent)/day or any other systemic use of immunemodifying drugs during a period starting from 3 months prior to first administration of the trial vaccine and ending at the End of Study Visit (EOS). The use of topical, inhaled, ophthalmic and nasal glucocorticoids is permitted.
• Administration or planned administration of immunoglobulins and/or any blood products during a period starting from 3 months prior to first administration of the trial vaccine and during the trial.
• Known uncontrolled coagulation disorder. Anticoagulant treatment under adequate control for cardiovascular prophylaxis or prophylaxis of thromboembolic disease or stroke in the setting of atrial fibrillation are permitted.
• Use of any investigational or non-registered drug or vaccine other than the trial vaccine within 30 days prior to the administration of the trial vaccine, or planned administration of such a drug or vaccine between enrollment in the trial and until the end of the clinical trial including follow-up. [For US Only]
• Involvement with this trial as research personnel.

Where it is running

• Central Alabama Research — Birmingham, Alabama, United States
• Achieve Clinical Research, LLC d/b/a Accel Research Sites — Birmingham, Alabama, United States
• Medical Affiliation Research Center — Huntsville, Alabama, United States
• Lenzmeier Family Medicine / CCT Research — Glendale, Arizona, United States
• Aventiv Research Inc. — Mesa, Arizona, United States
• Phoenix Clinical LLC — Phoenix, Arizona, United States
• Pain Center of Arizona — Phoenix, Arizona, United States
• Cognitive Clinical Trials, LLC — Phoenix, Arizona, United States
• Fiel Family and Sports Medicine/CCT Research — Tempe, Arizona, United States
• HOPE Research Institute — Tempe, Arizona, United States
• Tucson Neuroscience Research, LLC — Tucson, Arizona, United States
• Lynn Institute of the Ozarks — Little Rock, Arkansas, United States
• Hope Clinical Research, LLC — Canoga Park, California, United States
• Marvel Clinical Research 002, LLC — Huntington Beach, California, United States
• Join Clinical Trials — Huntington Park, California, United States
• Paradigm Clinical Research Center — La Mesa, California, United States
• Atella Clinical Research LLC — La Palma, California, United States
• Chemidox Clinical Trials Inc. — Lancaster, California, United States
• ARK Clinical Research — Long Beach, California, United States
• Matrix Clinical Research — Los Angeles, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• California Research Foundation — San Diego, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Lynn Institute of Denver — Aurora, Colorado, United States
• North Alabama Research Center, LLC — Athens, Alabama, United States

Full record on ClinicalTrials.gov

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