Modeling of Intracerebral Vascularization After Extracorporeal Membrane Oxygenation in Children
Recruiting now
Conditions studied: Extra Corporeal Membrane Oxygenation, Decanulated Alive
In brief
Extra corporeal membrane oxygenation (ECMO) is a transient supplementation technique that alleviates hemodynamic and ventilatory failure. Its implementation requires carotid arterial and jugular venous cannulation in newborns or children weighing less than 20 kg. The impact of ECMO on arterial circulation was studied by Doppler ultrasound and shows a redistribution of flows within the circle of Willis. This study aims to model cerebral flow in children who have been cared from jugulocarotid ECMO and compare cerebral hemodynamics according to the technique of reconstruction of the common carotid artery after decanulation (reconstruction or ligation).
Key facts
- Study ID
- NCT05237232
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 30
- Starts
- 2022-03-31
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-09-12
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- For everyone :
- Information and non-opposition of holders of parental authority
- Newborn, infant and child <20kg
- Hospitalization in pediatric and neonatal intensive care unit (PICU) of Trousseau Hospital
- Performing a Magnetic Resonance Angiography (MRA) as part of the treatment
- For patients treated with ECMO: study population
- Hemodynamic or respiratory failure
- Requiring the use of extracorporeal circulation with jugulo-carotid cannulation
- Weaned alive off Extra corporeal membrane oxygenation (ECMO)
- For patients with hypoxic-ischemic encephalopathy: control population
- hypoxic-ischemic encephalopathy diagnosed at birth
You may not qualify if…
- Contraindication to MRA
- Opposition of holders of parental authority
Where it is running
- Hôpital Trousseau — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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