Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot

Recruiting now · Not applicable

Conditions studied: Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death

In brief

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.

Key facts

Study ID

NCT05236153

Run by

Boston Children's Hospital

People needed

60

Starts

2022-11-04

Expected to finish

2024-01-01

Last updated by the study team

2023-02-08

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of tetralogy of Fallot (TOF) or double outlet right ventricle (DORV)
• Referred for transcatheter pulmonary valve replacement (TPVR) per routine clinical indications
• Weight >=25 kg

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.