Ganciclovir Resistant/Refractory Cytomegalovirus Infection in SOT Recipients and HSCT Patients
Recruiting now
Conditions studied: Cytomegalovirus Infections
In brief
The ReCySOHT study is a multicenter, retrospective, observational case-control study on the risk factors for developing a ganciclovir-resistant/refractory (GCV-RR) cytomegalovirus infection in patients receiving solid organ transplant (SOT) or hematopoietic stem cell transplant (HSCT). Aims of the study are to investigate the incidence of and risk factors for GCV-RR CMV infection in SOT recipients and HSCT patients in order to design further studies aimed at preventing and improving the patient management of GCV-RR CMV infections.
Key facts
- Study ID
- NCT05234723
- Run by
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- People needed
- 100
- Starts
- 2023-06-19
- Expected to finish
- 2028-02-28
- Last updated by the study team
- 2026-06-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All adult (≥ 18 years) patients who underwent SOT or HSCT developing CMV-infection treated with GC/VGC
- Ability to understand the purpose of the study and provide signed and dated informed consent
You may not qualify if…
- Lack of clinical and/or laboratory data regarding the type of CMV event
- Lack of the serological mismatch at transplantation
- Lack of the type of SOT or HSCT
- Lack of the patient and graft outcome at 30, 60 or 90 days after CMV event diagnosis
Where it is running
- Hospital Clinic — Barcelona, Spain (enrolling)
- Instituto Maimónides de Investigación Biomédica de Córdoba — Córdoba, Spain (enrolling)
- Istituto mediterraneo per i trapianti e terapie ad alta specializzazione (ISMETT) — Palermo, Palermo, Italy (enrolling)
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Bologna, Italy (enrolling)
- AOU Città della salute e della scienza — Torino, Italy (enrolling)
- Policlinico di Milano — Milan, Italy (enrolling)
- Azienda Ospedaliero-Universitaria di Modena — Modena, Italy (enrolling)
- Azienda Ospedaliera dei Colli — Naples, Italy
- Azienda Ospedale-Università Padova — Padova, Italy
- ASST dei Sette Laghi — Varese, Italy
- São João University Hospital — Porto, Portugal
- Gregorio Marañón General University Hospital — Madrid, Spain
- University Hospital 12 de Octubre — Madrid, Spain
- Centre hospitalier universitaire vaudois (CHUV) — Lausanne, Lausanne, Switzerland
- University Hospital Zurich — Zurich, Switzerland
- MD Anderson Cancer Center — Houston, Texas, United States
- Manchester University NHS Foundation Trust — Manchester, United Kingdom
- Institut Jules Bordet — Brussels, Belgium
- University Hospitals Leuven — Leuven, Belgium
- Helsinki University Central Hospital — Helsinki, Helsinki, Finland
- Centre Hospitalier Universitaire de Limoges — Limoges, Limoges, France
- Humanitas Research Hospital — Rozzano, Milano, Italy
- Ospedale San Martino — Genova, Italy
Full record on ClinicalTrials.gov
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